Why is the diabetic foot complex?
Neuropathy, arterial circulatory disorder, infection, pressure, hyperglycemia, and immune dysfunction may be present at the same time.
Initial evaluation
Wound depth, infection, circulation, neuropathy, the possibility of osteomyelitis, glycemic control, and the pattern of weight-bearing on the foot should be evaluated.
Local methods
Bagging, ozonated water, and ozonated oil are different local tools. In appropriate patients, they can be evaluated as complementary local options alongside fundamental wound care components such as debridement, infection management, circulatory support, and revascularization when necessary.
Evidence
2024 meta-analyses reported positive outcomes in some wound parameters. A 2026 umbrella review highlights that methodological and protocol differences across studies affect the interpretation of results. Current clinical signals support clarifying through larger studies which patient groups ozone can offer greater contributions to, with appropriate patient selection and in addition to standard wound care.
Ischemia and neuropathy
Neuropathic and ischemic wounds are not the same. If severe ischemia is present, the priority is ensuring adequate arterial blood flow.
Off-loading
Pressure reduction is the foundation of treatment, especially in neuropathic plantar wounds. If continuous mechanical load on the wound persists, the effect of biological/topical methods remains limited.
Our Approach in Our Bodrum Clinic
For those seeking information on this subject in Muğla and Milas, this guide explains application methods together with clinical evaluation. In Bodrum, medical history, current treatments, and expectations are addressed together during an individual physician evaluation.
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