Medical Topic

Ozonated Water: How Is It Prepared and How Is It Used on Wounds, Skin, and Mucosa?

Written by: Dr. Kerem Çağlayan Medically reviewed by: Dr. Kerem Çağlayan First published: September 3, 2026 Last updated: September 28, 2026

Short answerOzonated water is a product for local use prepared by dissolving medical ozone in appropriate water in a controlled manner. Compared to gaseous ozone, it provides local contact in liquid form on wound surfaces, skin, and certain mucosal areas.

In this guide

What is ozonated water? · Stability · Wound care · Oral mucosa · Oral and surgical sites · Difference from ozonated oil

What is ozonated water?

When ozone is dissolved in water, its local antimicrobial and biological effects can be investigated. It is particularly used for irrigation and surface care.

Stability

Dissolved ozone decomposes over time, converting back into oxygen. Ozonated water does not maintain the same properties for long periods like a conventional shelf product; preparation and usage conditions are important.

Wound care

It can be evaluated for the controlled local cleansing of wound surfaces. The most appropriate use is as a complementary local approach planned alongside fundamental wound care components such as debridement, circulation assessment, infection management, and off-loading.

Oral mucosa

In a 2026 randomized trial involving intensive care patients, ozonated water demonstrated good performance compared to certain comparator agents in preserving oral mucosal integrity.

Oral and surgical sites

Safe use and variable clinical outcomes have been reported in studies investigating irrigation for oral wound healing and after third molar surgery.

Difference from ozonated oil

Ozonated water is considered for rapid and superficial local use, whereas ozonated oil is evaluated for longer-term topical contact with more stable reaction products.

Our Approach at Our Bodrum Clinic

During an evaluation with Dr. Kerem Çağlayan in Bodrum, your complaints, medical history, and current treatments are considered together. For those seeking information about ozonated water in Muğla and Milas, this guide explains the application process and areas of use.

Physician information and contact →

Related ozone applications

References

Türk G, Özdemir S. Comparative effects of chlorhexidine, ozonated water, and hypochlorous acid for oral care. Oral Dis. 2026. View source
Efficacy of ozone therapy for oral mucosa wound healing: systematic review/meta-analysis. Clin Oral Investig. 2024.
Glória JCR, et al. Ozonized water in third molar surgery. BMC Oral Health. 2020.
Madrid Declaration on Ozone Therapy.

Medical editorial information

This content has been medically reviewed and approved by Dr. Kerem Çağlayan. It is intended for general education and does not replace an individual diagnosis or treatment plan.

Condition

Diabetic Foot and Chronic Wound

Clinical evaluation of circulation, neuropathy, infection, pressure, debridement, and supportive treatments in diabetic foot and chronic wound.

Treatment / Procedure

Chronic Wound Assessment and Wound Treatment

Holistic assessment of circulation, infection, pressure, debridement, dressing, ozone, and photobiomodulation in chronic wounds, diabetic foot, and venous/arterial ulcers.