Medical Guide
Physician-led explanations of medical conditions, biological mechanisms, diagnostics, treatments, healthy ageing and emerging clinical research.
Medical Topic
Does every meal have to be flawless in healthy eating? We evaluate the 80% approach in terms of the Mediterranean-style diet, ultra-processed foods, sustainability, and clinical nutrition.
Medical Topic
The association between the shingles vaccine and a lower risk of dementia has been replicated in data from Wales, Canada, and the US. We examine the power, limitations, and clinical significance of natural experiments.
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An artificial intelligence model that predicts the risk of type 2 diabetes from a 20-second speech recording was validated in 7,319 individuals. We examine the AUC, HbA1c validation, false positives, and limitations of clinical use.
Medical Topic
Why can starvation in anorexia nervosa become rewarding or compulsive over time? We evaluate the dopaminergic, orexinergic, and endocannabinoid systems using a current neurobiological model.
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Photobiomodulation (PBM) is a supportive option for side effects of cancer treatment, particularly for oral mucositis. 2026 meta-analyses, safety, red/NIR light, lymphedema, radiodermatitis, and difference from PDT.
Medical Topic
CD19 CAR-T is now being investigated not only in hematologic cancers, but also in autoimmune diseases such as lupus, myositis, systemic sclerosis, myasthenia gravis, and stiff person syndrome. We explain the evidence and risks.
Medical Topic
Nicotine may show short-term effects on attention; however, this does not make it a safe nootropic or longevity supplement. We distinguish cognition, the cardiovascular system, addiction, and nicotine replacement therapy.
Medical Topic
The accuracy of calorie, heart rate, and step measurements in wearable devices such as Apple Watch, Garmin, Fitbit, and Samsung is not the same. Which data should we interpret as a trend, and which as a clinical measurement?
Medical Topic
We evaluate the relationship between grandchild care and cognitive health through 2026 ELSA data and longitudinal studies. Social connection may be beneficial; however, causality and caregiver burden are important.
Medical Topic
Can nutrition affect sleep quality? We evaluate kiwi, tart cherry, the Mediterranean diet, tryptophan, caffeine, alcohol, and evening meal timing using current human studies.
Medical Topic
Ariadne Bio’s non-hallucinogenic 5-HT2A partial agonist named AB-300 targets apathy in Parkinson’s disease. Examine the mechanism, preclinical data, Phase 1b plan, and why it cannot yet be considered an efficacy result.
Medical Topic
Delays reported in Medicare’s WISeR artificial intelligence-supported prior-authorization pilot demonstrate why human-in-the-loop design is critical in clinical AI. How should technology, physician decision-making, and accountability be balanced?
Medical Topic
The Rosalind Franklin Institute’s STED microscope named Curie will examine tight junctions and cell-cell junctions in the intestinal epithelium at approximately 20 nm resolution. What could this technology change in Crohn’s and ulcerative colitis?
Medical Topic
Does unnecessary supplementation protect cognition in older adults with normal vitamin D levels? Examine the 6-year cohort of 5,065 individuals through the limits of causality, the dosing issue, and a targeted supplementation approach.
Medical Topic
In GLP-1 and GIP/GLP-1 therapies, how much of weight loss is fat, and how much is lean mass? Evaluate super responder, rapid weight loss, SEMALEAN data, protein, resistance exercise, and muscle strength monitoring with the level of evidence.
Medical Topic
Omega-3 index, EPA, and DHA: learn the clinical significance of this biomarker in the context of nutrition, triglycerides, cardiometabolic risk, and healthy aging.
Medical Topic
Creatine and healthy aging: learn its relationship with resistance exercise, muscle strength, sarcopenia, and cognitive energy metabolism within the framework of evidence and safety.
Medical Topic
Organ age: Learn that the heart, brain, muscle, and metabolic systems can age at different rates, and the role of organ-based risk assessment in a longevity plan.
Medical Topic
Wearable technologies and digital biomarkers: Learn about the role of HRV, sleep, resting heart rate, activity, and recovery data in longevity tracking.
Medical Topic
Mitochondrial health and longevity: learn about the role of energy metabolism, VO₂max, muscle performance, sleep, and metabolic flexibility in healthy aging.
Medical Topic
What is inflammaging? Examine the relationship of chronic low-grade inflammation with visceral fat, sleep, metabolic health, and healthy aging within a clinical framework.
Medical Topic
Visceral fat, waist circumference, and metabolic risk: learn about the relationship of intra-abdominal fat with insulin resistance, fatty liver, and healthy aging.
Medical Topic
ApoB and Lp(a): learn the clinical significance of these two biomarkers in the assessment of atherogenic particle burden, genetic cardiovascular risk, and longevity.
Medical Topic
CGM and metabolic flexibility: learn about the personalized use of continuous glucose monitoring in meal responses, sleep, exercise, and metabolic risk assessment.
