Medical Topic

Skin and Aesthetic Ozone Applications: Skin Quality, Regeneration, and Local Ozone Approach

Written by: Dr. Kerem Çağlayan Medically reviewed by: Dr. Kerem Çağlayan First published: September 3, 2026 Last updated: September 28, 2026

Short answerIn skin and aesthetic ozone applications, the medical oxygen-ozone mixture is investigated for the purpose of local biological response, microcirculation, and tissue regeneration. The method is not a conventional filler and does not have the same mechanism as botulinum toxin, fillers, or energy-based devices.

In this guide

Biological approach · Application principle · Combination with PRP · Crow’s feet and fine wrinkles · Safety · Combination approach

Biological approach

Investigated mechanisms are controlled redox response, Nrf2, microcirculation, fibroblast activity, collagen metabolism, and inflammatory signaling pathways. Mechanism data are not a guarantee of clinical rejuvenation.

Application principle

Skin thickness, elasticity, photoaging, pigmentation, vascular structure, and volume loss should be evaluated separately. Different anatomical regions of the face do not share the same risk profile.

Combination with PRP

A 2024 randomized controlled pilot study reported positive signals in facial aging measurements with the combination of PRP and volume-controlled ozone; the study is small and of a pilot nature.

Crow’s feet and fine wrinkles

Muscle activity is decisive in dynamic wrinkles. Ozone can rather be investigated in terms of skin quality and local tissue support; it should not be presented for the same purpose as botulinum toxin.

Safety

Mastery of facial anatomy is critical. In a 2025 case report, necrosis, scarring, and alopecia were reported following aggressive/inappropriate facial ozone injection. Aesthetic content should not downplay the risk of complications.

Combination approach

PRP, polynucleotide/PDRN, energy-based modalities, and ozone should be explained not as direct alternatives to one another, but as modalities with different biological targets.

Personalized evaluation in Bodrum

During an evaluation with Dr. Kerem Çağlayan in Bodrum, your complaints, medical history, and current treatments are addressed together. For those seeking information about skin and aesthetic ozone in Muğla and Milas, this guide explains the application process and areas of use.

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Related ozone applications

References

Camargo C, et al. PRP and volume-controlled ozone in facial rejuvenation: randomized controlled pilot study. An Acad Bras Cienc. 2024. PubMed: View source
Ozone therapy for dermatological conditions: systematic review.
Madrid Declaration on Ozone Therapy – subcutaneous/topical routes.

Medical editorial information

This content has been medically reviewed and approved by Dr. Kerem Çağlayan. It is intended for general education and does not replace an individual diagnosis or treatment plan.

Condition

Skin Aging and Wrinkles

Causes of skin aging, wrinkles, loss of elasticity, and changes in skin quality; evaluation and personalized treatment options.

Treatment / Procedure

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