Metabolic structure of diabetes
Insulin resistance, visceral adiposity, hepatic metabolic dysfunction, inflammation, endothelial dysfunction, and oxidative stress are interrelated. Therefore, metabolic health is not evaluated solely through a single glucose measurement.
Metabolic assessment
HbA1c, fasting glucose and insulin, triglyceride-HDL ratio, ApoB, hepatic steatosis, blood pressure, and body composition should be evaluated together.
Why is ozone being investigated?
Hyperglycemia can contribute to oxidative stress and endothelial dysfunction. In controlled hormetic applications of medical ozone, effects on the endogenous antioxidant/redox response, inflammatory signals, and microcirculation are being investigated.
Pilot human study
In a pilot study involving 21 patients with type 2 diabetes and 14 healthy volunteers, reductions in GDF-15 and LDL levels were reported in the diabetes group following major autohemotherapy. The exploratory nature of the study provides valuable preliminary data for confirming these metabolic signals in larger controlled studies.
HbA1c data
In a randomized study of 100 patients with diabetes and periodontal disease, a reduction in HbA1c was observed in both groups. The lack of a significant difference between groups suggests that rather than glycemic outcomes, ozone’s potential contribution to other targets such as inflammation, periodontal health, or redox response should be investigated separately.
Comprehensive treatment plan
The ADA 2026 approach personalizes lifestyle and pharmacotherapy according to glycemic target, obesity, atherosclerotic disease, heart failure, and renal disease. If an appropriate complementary target exists for medical ozone, it is evaluated in alignment with this fundamental metabolic treatment plan.
Our Approach at Our Bodrum Clinic
In metabolic assessment, alongside glucose control, we address insulin resistance, visceral adiposity, liver health, lipid profile, inflammation, and circulatory indicators together. When ozone is considered, we define the objective from the outset and monitor it alongside metabolic treatment through measurable parameters.
Related ozone guides
Ozone therapy: methods and clinical approach · All ozone guides
