Chemical structure · Differences from gas and water · Human data in diabetic foot · Interpretation of current evidence · Dermatological use · Product standardization
Chemical structure
Ozone reacts with the double bonds of unsaturated fatty acids to form ozonides, peroxides, and various oxidation products. Therefore, ozonated oil is a form that possesses different properties from gaseous ozone and provides longer-term topical contact.
Differences from gas and water
Gas provides a short-term local atmosphere; ozonated water is used for irrigation and surface cleansing; and ozonated oil is used for longer-term topical contact as distinct application tools.
Human data in diabetic foot
In a 2025 randomized controlled trial of 123 patients with Wagner 1–2 diabetic foot ulcers, adding ozonated olive oil to standard care was associated with greater improvement in wound scores. This result provides a positive clinical signal supporting further detailed investigation of ozonated oil as a supportive option for wound care in selected patients.
Interpretation of current evidence
A 2026 umbrella review reported that there are positive signals toward improvement in ozone studies on diabetic foot; however, the certainty level of the current evidence remains low to very low due to the number of studies, sample sizes, and differences between studies. The positive results in the 2025 randomized study suggest that ozonated oil may be a promising supportive option. Larger and well-designed studies will help to more clearly determine in which patient groups this approach can provide the greatest benefit and its role in standard wound care.
Dermatological use
Effects on local antimicrobial activity, epithelialization, and the inflammatory environment are being investigated. For skin complaints, establishing the correct diagnosis first and determining the role of ozonated oil within an appropriate topical approach through individualized assessment are essential.
Product standardization
The oil used in manufacturing, degree of ozonation, peroxide value, packaging, and storage conditions can affect product characteristics. Especially in open wound applications, product standardization and appropriate storage conditions are of importance for clinical safety.
Our Approach at Our Bodrum Clinic
We evaluate ozonated oil not as a standalone wound treatment, but in conjunction with the etiology of the wound, circulatory status, signs of infection, glycemic control, dressing needs, and other components of wound care. In appropriate patients, a topical ozone approach may be considered as part of an individualized plan supporting standard wound care.
Related ozone applications
References
- Vahedi S, et al. Topical ozonated olive oil RCT. Lipids Health Dis. 2025. View source
- Cacciatore S, et al. Effectiveness and Safety of Ozone Therapy in Humans: An Umbrella Review. Med Sci (Basel). 2026.
- Ozone therapy for dermatological conditions: systematic review.
- Madrid Declaration on Ozone Therapy.
