Key points
- The most extensively researched uses of ozone in the field of skin conditions are chronic wounds, infected wound care, and topical approaches such as ozonated oils.
- Results that may support wound healing have been reported in some human studies. Methodological and quality differences between studies require better definition of which patient groups and application protocols may show a more pronounced benefit.
- The mechanisms of different skin diseases such as eczema, psoriasis, acne, or fungal infections differ from one another; therefore, establishing an accurate dermatological diagnosis first and selecting the appropriate treatment approach accordingly is important.
- Medical ozone is administered under controlled conditions. Ozone gas must not be inhaled, and uncontrolled home-use applications should not be used.
How is medical ozone applied to the skin?
Medical ozone is an ozone-oxygen mixture produced from pure medical oxygen. Various methods have been investigated in the skin and wound area, such as closed bagging systems, controlled local applications, or ozonated oils. The choice of application is made according to the type of lesion, depth, infection status, circulation, and the person’s overall health condition.
Possible mechanisms
- Local oxidative effect on microorganisms
- Controlled redox signaling in the wound environment
- Changes associated with the inflammatory response and antioxidant defense systems
- Effects investigated on granulation, tissue repair, and local circulation
Demonstrating these mechanisms in laboratory or animal studies does not mean that the same effect has been clinically proven in every skin disease.
In which conditions has it been investigated?
A significant portion of human studies has focused on diabetic foot ulcers, chronic ulcers, infected wounds, and wound healing. In the dermatology literature, there are also smaller studies on acne, eczema, dermatophyte infections, and certain inflammatory skin conditions. While existing systematic reviews report promising results in some areas, they emphasize the need for larger and well-designed controlled trials.
Approach to chronic wounds
Success in chronic wounds does not depend solely on the product applied. Blood sugar control, circulatory assessment, pressure reduction, infection management, appropriate dressings, nutrition, and surgical treatment when necessary are essential components. If ozone is considered, it may be evaluated in selected patients alongside standard wound care as a complementary component that supports the healing environment.
Who requires careful evaluation?
If there is rapidly spreading redness, fever, foul-smelling discharge, tissue loss, circulatory impairment, or uncontrolled diabetes, standard medical evaluation is required without delay. In findings such as a suspicious mole, a non-healing crusted lesion, or recurrent bleeding, a dermatological examination should be performed first. This evaluation often ensures accurate and timely management of the problem.
Safety
Ozone gas is irritating to the respiratory tract and must not be inhaled. Concentration, application duration, closed system, and material selection should be determined by a trained physician. Open flames, improper equipment, or non-standardized home applications are not safe. If skin irritation develops, the application is re-evaluated.
Approach in our clinic
First, we evaluate the diagnosis of the skin finding, circulation, infection risk, and metabolic factors that affect healing. We take standard dermatology and wound care as the foundation; when its expected contribution can be monitored and is safe, we consider ozone as one of the complementary options that support this plan. The goal is to support the skin’s healing environment and avoid unnecessary procedures.
Frequently asked questions
Is ozone good for every skin disease?
The mechanisms of skin diseases are different. The potential role of ozone should be evaluated separately according to the diagnosis and level of evidence.
Is ozonated oil the same as medical ozone?
Product structure, active compounds, method of application, and dose control are different. Products with documented quality and stability information should be preferred.
Related content
References
- Modena DAO et al. Ozone Therapy for Dermatological Conditions: A Systematic Review.
- Fitzpatrick E et al. Ozone therapy for the treatment of chronic wounds: a systematic review.
- Republic of Turkey Ministry of Health. Regulation on Traditional and Complementary Medicine Practices.
