Evidence map
| Study | Design | Main finding | Comment |
|---|---|---|---|
| Nilforoushzadeh et al., 2024 | Systematic review · 23 studies | Positive outcomes in face-neck rejuvenation, skin laxity, and certain localized fat areas | Positive overall signal; a significant portion of studies have small sample sizes |
| Vidal et al., 2025 | Scoping review · 26 publications | 1 RCT, 23 case series, 1 case report, 1 pilot study | High protocol heterogeneity; prominent need for standardization |
| Modena et al., 2025 | Systematic review | Issue of standardization in parameters and indications, risk of bias | Emphasizes that study quality must be taken into account in efficacy/safety claims |
| Jowl study | Case series · n=9 | Favorable change in skin elasticity, thickness, and density; high satisfaction | Small sample size |
| Nasolabial/marionette study | Clinical study · n=10 | Reduction in wrinkle depth and area; improvement in dermal measurements | Objective biometric measurements present; sample size is small |
| Neck lines study | Clinical series | Biometric improvement on horizontal neck wrinkles | Region-specific positive data; larger comparative studies are needed |
| Gynecomastia 1470 nm study, 2026 | Prospective, single-blind randomized · n=30 | Favorable results in terms of aesthetic assessment/BREAST-Q and pain in the 1470 nm laser-assisted lipolysis group | Not Endolifting alone; laser-assisted lipolysis + liposuction protocol |
What did the 2024 systematic review say?
The systematic review evaluating 23 studies reported that the Endolift approach yielded favorable results in facial and neck lifting, skin laxity, wrinkles/lines, and certain localized fat areas. The review itself also emphasized that larger controlled studies are needed.
Why is the 2025 scoping review important?
This study is particularly valuable in demonstrating the structure of the literature. Of the 26 publications included, 23 were classified as case series and only one as a randomized controlled trial. This does not mean the method is “unstudied”; it indicates that most of the existing positive results come from earlier-stage clinical studies rather than high-level comparative evidence.
Key limitations in the studies
- Patient numbers are generally small
- Fiber diameter, energy, emission technique, and anatomical plane vary from study to study
- Follow-up periods differ
- Absence of a control group in many studies
- Difficulty of evaluating face, neck, and body regions under a single heading
How do we interpret these data clinically?
Current data provide a positive clinical signal for Endolifting. Conversely, generalizations such as “equal success in every region,” “permanent results in a single session,” or “an equivalent to surgery” go further than what the scientific literature supports. The most appropriate approach is to evaluate the anatomical region, tissue structure, goals, and alternative treatments together.
Why should data between Endolifting and laser lipolysis be read separately?
In some studies, the 1470 nm laser was used in conjunction with laser-assisted lipolysis and even aspiration/liposuction for more pronounced fat reduction. These results should not be conveyed directly as “standard facial Endolifting” results. The gynecomastia RCT is one of the best examples of this.
Our approach at our Bodrum clinic
We evaluate scientific data according to the application area and the design of the study. The aim is not to portray the method as stronger or weaker than it is, but to explain in which patient, for which goal, and compared to which alternatives it may be meaningful.
References
- Nilforoushzadeh MA, et al. Aesthetic Plast Surg. 2024. PMID: 38886198.
- Vidal GP, et al. Lasers Med Sci. 2025. PMID: 40116960.
- Modena DAO, et al. Lasers Med Sci. 2025. PMID: 39827299.
- Endolift laser for jowl fat reduction. PMID: 35083532.
- Efficacy evaluation of endolift laser for nasolabial folds and marionette lines. PMID: 37881043.
- Treatment of horizontal neck wrinkles by Endolift laser. PMID: 38634118.
- 1470 nm diode laser-assisted lipolysis in gynecomastia. PMID: 41710183.
You can review the Endolifting guide for the primary clinical framework in which research findings are evaluated alongside application options.
Written and medically reviewed by: Dr. Kerem Çağlayan
Last medical review: September 11, 2026
