Key points
- The type of allergy, its triggers, and accompanying conditions such as asthma form the basis of a personalized plan.
- In allergic rhinitis, trigger control, intranasal therapies, antihistamines, and allergen immunotherapy in appropriate patients are strong clinical options.
- The redox and immunomodulatory effects of medical ozone are being investigated with respect to allergic diseases; stronger human studies are needed to clarify in which patient groups clinical contribution may be more meaningful.
- Medical ozone in controlled medical administration is not the same as environmental ozone exposure. Ozone gas must not be inhaled.
How is an allergy evaluated?
Allergy can occur when the immune system develops an exaggerated response to a normally harmless substance. Runny nose, sneezing, eye complaints, skin findings, or respiratory symptoms may develop through different mechanisms. A detailed history, physical examination, and, when necessary, skin testing or specific IgE evaluation allow reaching an accurate diagnosis.
Standard treatment approach
Current ARIA recommendations guide the treatment of allergic rhinitis according to the type and severity of symptoms. Intranasal corticosteroids, intranasal or oral antihistamines, appropriate combinations, nasal saline irrigation, and allergen immunotherapy in selected patients are fundamental options. If medical ozone is being considered, its complementary role compatible with this treatment framework is evaluated.
Where does ozone administration stand?
Medical ozone is the administration of an ozone-oxygen mixture, produced in a controlled manner from pure medical oxygen, by a physician using methods defined in regulations. Its effects on oxidative signaling, antioxidant response, and inflammatory pathways are being investigated mechanistically and clinically. For different clinical presentations such as allergic rhinitis, asthma, and urticaria, the clinical role is expected to be defined more clearly through disease-specific studies.
The difference between environmental ozone and medical ozone
Ozone in the air is a pollutant that can irritate the respiratory tract. This is different from controlled medical ozone administration. In safe administration, inhalation is avoided, and the route of administration is selected according to the clinical objective.
Priority in acute allergic conditions
Acute shortness of breath, uncontrolled asthma attacks, anaphylaxis, or rapidly progressing angioedema require emergency medical evaluation. Complementary approaches such as medical ozone can be brought to the agenda after the acute condition is brought under control and the individual’s overall status is evaluated.
Our approach in our Bodrum clinic
First, we determine the actual trigger of the allergy, the severity of symptoms, and accompanying diseases. By preserving existing effective treatments, we evaluate individually whether medical ozone has an appropriate complementary role. The goal is to safely control symptoms, increase daily comfort, and reduce unnecessary restrictions.
Frequently asked questions
Can ozone contribute to allergy complaints?
Due to redox and immunomodulation mechanisms, this area is being investigated. It is thought that clinical response may vary depending on the type of allergy, route of administration, and individual characteristics; therefore, expectations and monitoring goals are determined individually.
Can allergy medications be discontinued?
Medication adjustments should only be made based on symptoms, examination findings, and physician evaluation. Complementary applications are only meaningful for re-evaluating existing treatment when clinical response and safety are addressed together.
Related content
References
- ARIA-EAACI. Allergic Rhinitis and Its Impact on Asthma: 2024–2025 recommendations.
- Republic of Türkiye Ministry of Health. Regulation on Traditional and Complementary Medicine Practices.
- Zhang X et al. The role of ozone in the pathogenesis of allergic rhinitis.
